The Human isletOrganDOTTM System A novel 3D human cell based model for diabetes research

Cell based models for diabetes research have to date, relied on cell lines or intact rodent and human isolated islets, but both models have limitations.

Using a proprietary technology licensed exclusively from Capsant Neurotechnologies, Asterand has developed the isletOrganDOT^TM system. This human pancreatic islet cell model offers advancements in functionality, robustness, throughput and study design, allowing us to provide our clients with relevant human data on the effects of test compounds in a rapid and reproducible manner.

Specificially, isletOrganDOTs have been shown to:

• Contain representative islet cell populations
• Exhibit reproducible glucose stimulated insulin secretion between donors
• Respond to secretagogues

How the OrganDOT^TM System Works
Freshly isolated and intact human pancreatic islets sourced from multi-organ transplant donors are dispersed into single cells and embedded on a membrane. Fed basolaterally with culture medium, over time the cells re-aggregate and retain islet-like functionality for up to 14 days. isletOrganDOTs can be challenged with physiological and pharmacological agents and secreted mediators measured.

For further information, contact us at advantage@asterand.com