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font-size: 12px; color: #BE0000; font-family: Arial, Helvetica, sans-serif; text-indent: 35pt;">Autoradiography</a></td> </tr> <tr> <td height="10"></td> </tr> <tr> <td height="30" class="FR_Menu" onmouseover="this.className='FR_Menu_Over';" onmouseout="this.className='FR_Menu';"><div class="IMG_Right"><img src="../images/space.gif" name="img_02" width="6" height="6" id="img15" /></div><a href="../target_validation/core.htm" >Core Capabilities</a></td> </tr> </table> <td style="width: 990px"> <table> <tr> <td style=" width: 620px"> <div id="Padding3"> <h1>XpressWay<sup>TM</sup> Profile Examples</h1> </div> </td> <td><img alt="GryDiv" src="../images/PhaseZERO.jpg" /></td> </tr> </table> <p id="Target Validation"><b>Target Validation </b> <br /> <br /> An XpressWay<sup>®</sup> Profile report will display the complete expression of a single target in a number of human tissues. In the example below, the expression of Eotaxin 3 is shown in four human respiratory tissues. <br /> <br /> <img alt="" src="../target_validation/iMG1.gif"> <br /> <br /> XpressWay<sup>®</sup> Profiles may be used for a range of GPCRs in select tissues, such as human CNS tissue. XpressWay<sup>®</sup> Profiles are currently available for ~300 GPCRs. In the example below, the GPR57 gene expression is prevalent in nervous tissues as highlighted. <br /> <br /> <img src="../target_validation/iMG2.gif"> <img alt="" src="../target_validation/iMG2-2.gif"> <br /> <br /> XpressWay<sup>®</sup> Profiles may also be used to express a single gene across all 72 human tissues, such as MMP12, which is shown in the example below. <br /> <br /> <img src="../target_validation/iMG3.gif"> <br /> <br /> <br /> <p id="Characterization and Validation of Research Antibodies"><b>Characterization and Validation of Research Antibodies</b> <br /> XPressWay<sup>®</sup> Profiles are valuable in confirming or recommending the most advantageous positive control tissues for validation and characterization of research antibodies. When unsure of a target's expression in human tissues, XpressWay<sup>®</sup> profiles are used to select an optimal positive control tissue <br> <Br> Many times a customer's antibody may be raised against an other tissue type not previously considered <br> <Br> Additional value is gained with confirmation of the best tissue of choice for target expression and an increased likelihood of a successful <A href="../target_validation/antibodysupport.htm">antibody validation assay</A> <br /> <br /> <br /> <img src="../target_validation/iMG5.gif"> </p> <br /> <p id="Safety Profiling"><b>Safety Profiling </b> <br /> XpressWay<sup>®</sup> Profiles are valuable tool to identify expression of toxicology related genes in tissues which may be associated with potential side-effect liabilities. This data set example below represents that the expression of CYP3A4. <br /> <br /> <img alt="" src="../target_validation/iMG3-4.gif"> </p> <p>For further information, contact us at <a href="mailto:customerservice@asterand.com?subject=INQUIRY - XpressWay"! Profiles"; mailto:customerservice @ asterand.com?? id=a:link >customerservice@asterand.com</a></p> </td> </tr> </table> <br /> <table align="center" width="1000" border="0" cellspacing="0" cellpadding="0"> <tr valign="middle"> <td style="font-size: 8pt; color: gray; font-family: Tahoma; width: 900px;" align="left"> <font style="font-size: 10px; color: gray; font-family: Tahoma;">© 2010 Asterand plc. 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