Target Evaluator® Database

The sequencing of the human genome has identified a vast number of potentially interesting targets. The challenge now is to evaluate these targets and select those which are relevant to human disease. Critical for this evaluation process is to identify where these targets are expressed in a wide range of human tissues to ascertain which tissues contain the highest level of expression and to link this expression to a potential therapeutic use.

Asterand's TargetEvaluator^® adds value to the data in XpressWay^® Profiles, which is found in Profile Reports (click here for a sample 216 data-point report). Asterand's TargetEvaluator^® proprietary software will deliver the information you need to confirm, alter or negate therapeutic opportunities for your targets of choice. Our combination of human tissue-based appropriate technologies and intellectual strength and experience, will enable you to select and stratify genes of interest and identify those representing the greatest opportunity for further development in the following ways:

• Increase the speed and efficiency of your target validation and have more confidence in the targets you select
• Prioritize your targets with confidence using human data and concentrate your development resources
• Evaluate your targets in human tissues and identify potential side effect liabilities at an early stage
• Understand the linkage between gene targets and fully exploit their therapeutic potential
• Uncover alternative therapeutic opportunities at the earliest stage and expand your patent portfolio
• Reduce the risk of failure in later development and loss of investment due to species variation

Gene families expressed as a percentage of over 2000 gene expression profiles contained in Asterand's TargetEvaluator®

Gene Expression Database

TargetEvaluator^® is a comprehensive database of expression of gene transcripts in non-diseased human tissues, together with proprietary software tools which can be used to view these data.

For companies which have either invested in DNA sequence databases, DNA microarray analysis, or have already identified key targets, Asterand's TargetEvaluator^® represents the next logical step in the validation process adding greater value to drug discovery programs.

TargetEvaluator^® is a follow on product for those using genomic databases allowing multiple genes to be selected for profiling through our arrays of non-diseased human tissues, enabling decisions to be made based on their distribution in the human body.

TargetEvaluator^® users are provided with the ability to review expression of their targets in multiple formats. Asterand's specific expertise in Gene Expression supports critical data need, while providing a valuable database and interface which meets the various desired reviewing preferences of our customers.

Screen shots taken from Asterand's TargetEvaluator® showing examples of search tools, mean data presentation and visual comparison of two gene expression profiles in the form of a Stellar plot.

The components of Asterand's TargetEvaluator^® are complementary and provide a comprehensive tool for the validation of proprietary and public domain gene targets. The size and scope of each project is determined as part of an interactive discussion with Asterand and is designed to meet the needs of the customer.

For further information, contact us at advantage@asterand.com.